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Fluidic Programmable Biomolecular Array (FPBA)

                     

The FPBA microchip is an inexpensive and disposable fluidic microchip that allows for sophisticated manipulation of probes, samples, and wash liquids. The fluidic workstations will provide a stage for customers to program the FPBA microchips in order to label the probe spots on the FPBA microchip with specified molecules and a stage for on-chip genetic reaction and real-time analysis. The FPBA technology will provide a highly robotic and flexible platform for clinical genetic diagnostics. This product will make genetic testing widely available in a decentralized mode for physician’s practices and in tertiary care centers with large central laboratories.

 

The main advantages of the FPBA Technology are:

 

  • High speed 

With microfluidic channels, the biochemical reaction is accelerated.

  • Ease-of-use, no human interference, and no environmental requirements

All liquid manipulations are inside the FPBA microchip. User only needs to load the sample and reagent into the microchip. Probe coupling and target delivery are done in the capillary and the microchannel, which eliminates possible contamination and reduces the requirements of the operation environment.

 

  • Flexible assay format

User can quickly and simply program custom microarray assays. The same unit can be used for either DNA, protein or cell assays.

 

  • High reliability and reproducibility

The surface property of the each spot is much more uniform than that of the whole glass slide. The probe configuration is done on each spot by capillary liquid delivery to the spot, instead of pipette spotting. For these two reasons, probe coupling on each spot is much more consistent than that on the slide.

The sample is driven forwards and backwards in the microchannel connected with the each spot. Hybridization occurs on each spot by dynamic reaction. It can be expected that the dynamic reaction will reduce sample amount and reaction time, and increase the efficiency of target sample usage, and analysis reliability and reproducibility.

 

  • Multiple Sample Target

Multiple targets can be loaded in the different loading reservoirs on the FBPA microchip. Target analysis on the same chip at same time makes sample comparison and quality control easier.

  • Low cost

The material used for the FPBA microchip is less expensive than glass, silica, and quartz. The fabrication procedure is flexible, allowing it to be an excellent method for making prototype parts and subsequently for producing short-to-medium productions.  As quantities raise, casting production processes will make production more economical.

 

The market desires an automatic genetic analysis method and system that will identify mutations readily and accurately; costs significantly less than current genome analysis systems; use less expensive consumables; and require less technical expertise and hands-on time. Our target markets are pharmaceutical companies for genetic research and clinical laboratories for genetic diagnostics.